HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation
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چکیده
منابع مشابه
HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation.
We provide evidence that the human papillomavirus (HPV) E2 protein regulates HPV late gene expression. High levels of E2 caused a read-through at the early polyadenylation signal pAE into the late region of the HPV genome, thereby inducing expression of L1 and L2 mRNAs. This is a conserved property of E2 of both mucosal and cutaneous HPV types. Induction could be reversed by high levels of HPV-...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2012
ISSN: 0261-4189
DOI: 10.1038/emboj.2012.147